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59 Gnaeus Domitius Corbulo
, Roman commander in the east captured Tigranocerta in Mesopotamia after defeating the Parthia
ns, he set up a new ruler, Tigranes as ruler of Armenia.
114 Trajan
defeated the Parthia
ns and overran Armenia
and northern Mesopotamia
115 Trajan
is cut off in southern Mesopotamia after his invasion of that region.
117 Hadrian returns large parts of Mesopotamia to the Parthia
ns as part of a peace settlement.
165 Avidius Cassius takes Nisibis and conquers the north of Mesopotamia.
166 End of the war with Parthia
. The Parthians leave Armenia
and eastern Mesopotamia, with both becoming Roman protectorates.
171 Mesopotamia becomes a province of the Roman Empire.
195 Vologases IV of Parthia
invaded Mesopotamia, which was under Roman rule.
197 Septimus reconstitutes the Province of Mesopotamia under an equestrian governor commanding two legions.
199 Mesopotamia is partitioned into two Roman provinces divided by the Euphrates
, Mesopotamia and Osroene
.
217 Rome retains Mesopotamia under a treaty with Parthia
.
237 Ardashir I of Persia renews his attacks on the Roman province of Mesopotamia.
244 Rome loses Mesopotamia and Armenia
to the Sassanides.
341 Thousands of Christians are executed at Seleucia in Mesopotamia.
343 Emperor Constantius II
invades Adiabene (Mesopotamia).
364 Jovian
surrenders Mesopotamia to the Persians.
748 An earthquake
strikes the Middle East from northern Egypt
to northwestern Mesopotamia, destroying many remnants of Byzantine
culture.
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