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1493 Christopher Columbus
leaves the New World.
1493 Pope Alexander VI
divides the New World between Spain
and Portugal
along the Demarcation Line.
1494 Spain
and Portugal
sign the Treaty of Tordesillas which divides the New World between the two countries.
1497 Amerigo Vespucci allegedly leaves Cádiz
for his first voyage to the New World.
1498 Bartholomew Columbus, brother of Christopher Columbus
, founds the city of Santo Domingo
, now part of the Dominican Republic
, making it the oldest European City and permanent settlement in the New World.
1502 Christopher Columbus
leaves Spain
for his fourth and final trip to the "New World".
1503 Seville
in Castile is awarded exclusive right to trade with the New World.
1538 The first University
of the New World is founded the Universidad Santo Tomás de Aquino.
1552 Spain
's Bartolomé de Las Casas publishes his attack on colonial practices in the New World, A Short Account of the Destruction of the Indies.
1607 Ship ''Gift of God'' of the Plymouth Company arrives at the mouth of the modern-day Kennebec River in Maine
. English
colonists establish a ''Fort St. George'', also known as the Popham Colony. The settlement lasts little more than a year before residents return to England
in the first ocean going ship built in the New World, a 30-ton pinnace, called ''The Virginia''.
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