Pandemic: Timeline

165   A pandemic known as the Antonine Plague breaks out in Rome after the Roman army returns from Parthia Parthia

Parthia was a civilization situated in the northeast of modern Iran, but at its height covering all of ... 

. The plague significantly depopulates the empire.

1918   August — "Spanish Flu" Influenza Influenza

Influenza, commonly known as the flu, is an infectious disease [i] that infects bird [i]s and mammal [i] ... 

 becomes pandemic; over twenty-five million people die in the following six months (almost two times as many as died during the war).

1919   November — At end of month health officials declare the global Spanish Flu Pandemic over

1957   The Asian Flu pandemic begins in China China

China is a cultural region [i] and ancient civilization [i] in East Asia [i]. ... 

.